Synthetic PHOX2B blocking peptide for IB
15 amino acids near the center of human PHOX2B.
Human, mouse, rat
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008]
RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity
PHOX2B; paired-like homeobox 2b; PMX2B; NBLST2; NBPhox; paired mesoderm homeobox protein 2B; neuroblastoma Phox; PHOX2B homeodomain protein; paired mesoderm homeobox 2b; neuroblastoma paired-type homeobox protein