General Notes
This product (Catalog No. CABT-BL5322) is a rabbit-derived polyclonal antibody raised against human OR6C75. This antibody exhibits cross-reactivity with OR6C75 from rat. It has been affinity purified by Protein A. OR6C75 is a protein-coding gene in humans that encodes the olfactory receptor family 6 subfamily C member 75, a G protein-coupled receptor (GPCR) specialized for detecting odorant molecules in the nasal cavity to initiate the perception of smell. This receptor belongs to the largest gene family in the human genome, comprising over 400 olfactory receptor genes, and shares a characteristic seven-transmembrane domain structure with other GPCRs involved in sensory signaling. Located on the plus strand of chromosome 12 at position 12q13.2 (GRCh38: 55,362,975-55,369,279), the gene spans approximately 6.3 kilobases and produces a 312-amino-acid protein with a predicted molecular mass of 35,372 Da. Functionally, OR6C75 enables G protein-coupled receptor signaling and olfactory receptor activity, participating in pathways for sensory perception of smell and detection of chemical stimuli. Expression is primarily observed in olfactory epithelium, consistent with its role in olfaction, though proteomic data suggest broader tissue distribution including primordial germ cells and neural tissues. The gene shows high evolutionary conservation, with orthologs in mammals such as mice (87.27% similarity) and dogs (87.93%), indicating its ancient origin in chordates. Notable associations include links to ocular disorders like hereditary choroidal atrophy and partial central choroid dystrophy, potentially through genomic variants, though causal mechanisms remain under investigation. Genome-wide association studies (GWAS) have also implicated nearby regions in traits such as body height and risks for acute myeloid leukemia, highlighting OR6C75's position in a gene-dense chromosomal area prone to structural variations. With a residual variation intolerance score of 84.1%, the gene exhibits low tolerance for mutations, underscoring its functional importance.
CABT-BL5322 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200) applications.
CABT-BL5322 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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