NOTCH2 blocking peptide

Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the NOTCH family.Contains 6 ANK repeats.Contains 35 EGF-like domains.Contains 3 LNR (Lin/Notch) repeats.

Format

Liquid

Buffer

PBS with 0.02% sodium azide

Preservative

0.02% Sodium Azide

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. PBS with 0.02% sodium azide

Entrez Gene ID

Antigen Description

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Function

calcium ion binding; ligand-activated RNA polymerase II transcription factor binding transcription factor activity; protein binding; receptor activity;

Synonyms

NOTCH2; notch 2; hN2; AGS2; HJCYS; neurogenic locus notch homolog protein 2; Notch homolog 2;