Anti-NCAPG monoclonal antibody (DMABT-H13892)

Mouse anti-Human NCAPG monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5C2
Species Reactivity
Human
Immunogen
HCAP-G (AAH00827, 336 a.a. ~ 435 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
NCAPG; non-SMC condensin I complex, subunit G; condensin complex subunit 3; CAP G; chromosome condensation protein G; FLJ12450
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NCAPG (Non-SMC Condensin I Complex Subunit G) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase. GO annotations related to this gene include binding. This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants.
Antigen Description
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene. CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation. 0The function about NCAPG antigen include protein binding.
Pathway
Aurora B signaling, organism-specific biosystem.

Citations


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References


Liskova, L; Susor, A; et al. Detection of condensin I and II in maturing pig oocytes. REPRODUCTION FERTILITY AND DEVELOPMENT 22:644-652(2010).

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