Anti-SMC1B monoclonal antibody (CABT-22139MH)

Mouse anti-Human SMC1B monoclonal antibody for WB, IF, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
7B21
Species Reactivity
Human
Immunogen
SMC1L2 (NP_683515, 551 a.a. ~ 661 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
structural maintenance of chromosomes 1B; bK268H5; FLJ43748; bK268H5.5; mitosis-specific chromosome segregation protein like protein beta; structural maintenance of chromosomes protein 1B
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SMC1B (Structural Maintenance Of Chromosomes 1B) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell cycle. An important paralog of this gene is SMC1A. SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al. , 2001 [PubMed 11564881]).
Antigen Description
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al. , 2001
Mouse monoclonal antibody raised against a partial recombinant SMC1L2. Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene. SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis. 0The function about SMC1B antigen include ATP binding; nucleotide binding.
Pathway
Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Oocyte meiosis, organism-specific biosystem; Oocyte meiosis, conserved biosystem.

Citations


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References


Nurudeen, SK; Shirazi, M; et al. Structural Maintenance of Chromosome 1b(SMC1-b) Expression in Aging Human Oocytes.. REPRODUCTIVE SCIENCES 21:115A-115A(2014).

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