Anti-PTPRM monoclonal antibody, clone U21BG2B9

Antibody Isotype

IgG1

Clone

U21BG2B9

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human PTPRM.

Conjugate

Application Notes

WB (1:1000); Immunoprecipitation (1 ug) & The optimal working dilution should be determined by the end user.

Alternative Names

protein tyrosine phosphatase, receptor type, M; MGC166994; PTPRL1; R-PTP-MU; RPTPU; protein tyrosine phosphatase mu; hR-PTPu; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; receptor-type tyrosine-protein phos

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
Mouse monoclonal antibody raised against recombinant PTPRM.

Pathway

Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Nectin adhesion pathway, organism-specific biosystem.