Anti-PROCR monoclonal antibody (CABT-21530MH)

Mouse anti-Human PROCR monoclonal antibody for sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
N26B21
Species Reactivity
Human
Immunogen
PROCR (AAH14451, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
protein C receptor, endothelial; CCCA; EPCR; MGC23024; CCD41; OTTHUMP00000030729
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PROCR (Protein C Receptor) is a Protein Coding gene. Diseases associated with PROCR include purpura fulminans and thrombophilia. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include receptor activity. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
Antigen Description
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
Mouse monoclonal antibody raised against a full length recombinant PROCR. Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene. PROCR has also recently been designated CD201 (cluster of differentiation 201). 0The function about PROCR antigen include receptor activity.

Citations


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References


Lee, JE; Kim, C; et al. Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression. MOLECULAR CANCER THERAPEUTICS 14:470-479(2015).
Zhang, HY; Yang, HW; et al. Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line. CYTOKINE 53:231-238(2011).

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