Anti-PRKAG2 monoclonal antibody, clone 4D5

Antibody Isotype

IgG2a

Clone

4D5

Species Reactivity

Human

Immunogen

PRKAG2 (AAH20540, 191 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

protein kinase, AMP-activated, gamma 2 non-catalytic subunit; AAKG2; H91620p; AMPK gamma2; CMH6; AMPK subunit gamma-2; WPWS; 5"-AMP-activated protein kinase subunit gamma-2; AAKG; OTTHUMP00000211956; OTTHUMP00000211953; OTTHUMP00000211954; OTTHUMP00000211

Entrez Gene ID

UniProt ID

Antigen Description

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Mouse monoclonal antibody raised against a partial recombinant PRKAG2.

Pathway

AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy Metabolism, organism-specific biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem