Anti-NAPG monoclonal antibody (CABT-15957MH)

Mouse anti-Human NAPG monoclonal antibody for WB, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5C6
Species Reactivity
Human
Immunogen
NAPG (NP_003817, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
N-ethylmaleimide-sensitive factor attachment protein, gamma; gamma-soluble NSF attachment protein; SNAP-gamma; soluble NSF attachment protein; GAMMASNAP; gamma SNAP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
NAPG (NSF Attachment Protein Gamma) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.
Antigen Description
This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.
Mouse monoclonal antibody raised against a partial recombinant NAPG. Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Gamma-soluble NSF attachment protein is a protein that in humans is encoded by the NAPG gene. NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process. The function about NAPG antigen include binding; protein binding.

Citations


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References


Berdiev, BK; Jovov, B; et al. ENaC subunit-subunit interactions and inhibition by syntaxin 1A. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 286:F1100-F1106(2004).
Peter, F; Wong, SH; et al. alpha-SNAP but not gamma-SNAP is required for ER-Golgi transport after vesicle budding and the Rab1-requiring step but before the EGTA-sensitive step. JOURNAL OF CELL SCIENCE 111:2625-2633(1998).

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