Anti-MSC monoclonal antibody (CABT-18521MH)

Mouse anti-Human MSC monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2E2
Species Reactivity
Human
Immunogen
MSC (NP_005089, 103 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
musculin; MYOR; ABF-1; activated B-cell factor 1, homolog of mouse musculin; bHLHa22; activated B-cell factor-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
MSC (Musculin) is a Protein Coding gene. Among its related pathways are Id Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is TCF24. The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.
Antigen Description
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.
Mouse monoclonal antibody raised against a partial recombinant MSC. Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. Musculin is a protein that in humans is encoded by the MSC gene. 0The function about MSC antigen include DNA binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity.
Pathway
Id Signaling Pathway, organism-specific biosystem.

Citations


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References


Robb, L; Brodnicki, T; et al. Assignment of the human helix-loop-helix transcription factor gene Musculin/Activated B-Cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1. GENOMICS 57:318-319(1999).
Yu, LM; Mikloucich, J; et al. MyoR is expressed in nonmyogenic cells and can inhibit their differentiation. EXPERIMENTAL CELL RESEARCH 289:162-173(2003).

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