Anti-IFT20 monoclonal antibody (CABT-15725MH)

Mouse anti-Human IFT20 monoclonal antibody for WB, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4G4
Species Reactivity
Human
Immunogen
IFT20 (NP_777547, 1 a.a. ~ 148 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
intraflagellar transport 20 homolog (Chlamydomonas); intraflagellar transport protein 20 homolog; hIFT20; intraflagellar transport protein IFT20
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IFT20 (Intraflagellar Transport 20) is a Protein Coding gene. Diseases associated with IFT20 include retinitis pigmentosa. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. GO annotations related to this gene include opsin binding. This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al. , PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.
Antigen Description
Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11. 1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.
Mouse monoclonal antibody raised against a full-length recombinant IFT20. Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. 0The function about IFT20 antigen include protein binding.

Citations


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References


Baker, SA; Freeman, K; et al. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. JOURNAL OF BIOLOGICAL CHEMISTRY 278:34211-34218(2003).
Jurczyk, A; Gromley, A; et al. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. JOURNAL OF CELL BIOLOGY 166:637-643(2004).

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