Anti-HLA-DMB monoclonal antibody, clone 6H22

Antibody Isotype

IgG2b

Clone

6H22

Species Reactivity

Human

Immunogen

HLA-DMB (NP_002109, 22 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

major histocompatibility complex, class II, DM beta; class II histocompatibility antigen, M beta chain; RING7; D6S221E; Really interesting new gene 7 protein; OTTHUMP00000178732; HLA class II histocompatibility antigen, DM beta chain; OTTHUMP00000029257;

Entrez Gene ID

UniProt ID

Antigen Description

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Mouse monoclonal antibody raised against a partial recombinant HLA-DMB.

Pathway

Adaptive Immunity Signaling, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem