Anti-HES5 monoclonal antibody (CABT-18331MH)

Mouse anti-Human HES5 monoclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4C7
Species Reactivity
Human
Immunogen
HES5 (NP_001010926, 28 a.a. ~ 121 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
hairy and enhancer of split 5 (Drosophila); bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; transcription factor HES-5; OTTHUMP00000000867
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Diseases associated with HES5 include fetal valproate syndrome. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4. This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
Antigen Description
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
Mouse monoclonal antibody raised against a full length recombinant HES5. Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene. 0The function about HES5 antigen include DNA binding; chromatin binding; double-stranded DNA binding.
Pathway
CDC42 signaling events, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; SIDS Susceptibility Pathways, organism-specific biosystem.

Citations


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References


Chen, LH; Al-Awqati, Q; et al. Segmental expression of Notch and Hairy genes in nephrogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 288:F939-F952(2005).
Saravanamuthu, SS; Gao, CY; et al. Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation. DEVELOPMENTAL BIOLOGY 332:166-176(2009).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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