Anti-HES5 monoclonal antibody (CABT-18331MH)
Mouse anti-Human HES5 monoclonal antibody for WB, ELISA
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HES5 (NP_001010926, 28 a.a. ~ 121 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
hairy and enhancer of split 5 (Drosophila); bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; transcription factor HES-5; OTTHUMP00000000867
HES5 (Hes Family BHLH Transcription Factor 5) is a Protein Coding gene. Diseases associated with HES5 include fetal valproate syndrome. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include chromatin binding and protein dimerization activity. An important paralog of this gene is HES4. This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
Mouse monoclonal antibody raised against a full length recombinant HES5. Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene. 0The function about HES5 antigen include DNA binding; chromatin binding; double-stranded DNA binding.
CDC42 signaling events, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem; Notch signaling pathway, conserved biosystem; SIDS Susceptibility Pathways, organism-specific biosystem.
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Mahjoub, M; Sassi, N; et al. Expression patterns of Notch receptors and their ligands in human osteoarthritic and healthy articular cartilage. TISSUE & CELL 44:182-194(2012).
Osipo, C; Patel, P; et al. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. ONCOGENE 27:5019-5032(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.