Anti-FBXO2 monoclonal antibody, clone 2H5

Antibody Isotype

IgG1

Clone

2H5

Species Reactivity

Human

Immunogen

FBXO2 (AAH25233, 1 a.a. ~ 297 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

F-box protein 2; NFB42; FBX2; Fbg1; Fbs1; F-box only protein 2; OCP1; organ of Corti protein 1; F-box gene 1; OTTHUMP00000002066

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
Mouse monoclonal antibody raised against a full length recombinant FBXO2.

Pathway

Adaptive Immunity Signaling, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem