Anti-CTSL2 monoclonal antibody (CABT-24077MH)

Mouse anti-Human CTSL2 monoclonal antibody for WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
CW662
Species Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues surrounding amino acids 21 of human CTSL2.
Conjugate
Unconjugated

Applications


Application Notes
WB (1-4 μg/mL); Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20-30 μg/mL) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
cathepsin L2; CATL2; CTSV; MGC125957; CTSU; cathepsin L2, preproprotein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CTSV (Cathepsin V) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Immune System. GO annotations related to this gene include protein complex binding and cysteine-type endopeptidase activity. An important paralog of this gene is CTSW. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified.
Antigen Description
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified.
Mouse monoclonal antibody raised against synthetic peptide of CTSL2. Cysteine protease. May have an important role in corneal physiology. Cathepsin L2, also known as cathepsin V and encoded by the CTSL2 gene, is a human gene. 0The function about CTSL2 antigen include aminopeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding.
Pathway
Endochondral Ossification, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem.

Citations


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References


Tetu, B; Popa, I; et al. Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas. MODERN PATHOLOGY 21:1002-1010(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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