Anti-COL1A1 monoclonal antibody, clone 4H4

Antibody Isotype

IgG3

Clone

4H4

Species Reactivity

Human; Mouse

Immunogen

COL1A1 (NP_000079, 1021 a.a. ~ 1109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4; collagen of skin, tendon and bone, alpha-1 chain; Alpha-1 type I collagen; pro-alpha-1 collagen type 1; collagen alpha 1 chain type I; OTTHUMP00000192905

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Mouse monoclonal antibody raised against a partial recombinant COL1A1.

Pathway

Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Collagen adhesion via GPVI, organism-specific biosystem; Collagen adhesion via Gp IV, organism-specific biosystem