Human H2AFY2 blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

H2AFY2 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Gene ID

55506

UniProt ID

Q9P0M6

Synonyms

H2AFY2; H2A histone family, member Y2; macroH2A2; core histone macro-H2A.2; mH2A2; histone macroH2A2; core histone macroH2A2.2;