Anti-MXD4 (aa 197-209) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide: GPHCRRLGRPALS, corresponding to C terminal amino acids 197-209 of Human MAD4.

Conjugate

Application Notes

WB: 0.5-2μg/ml.

Alternative Names

MXD4; MAX dimerization protein 4; max dimerization protein 4; bHLHc12; MAD4; MST149; MSTP149; MAD 4; Mad4 homolog; Max associated protein 4; Max dimerization protein 4; Max interacting transcriptional repressor MAD4; MST 149; MST149; MSTP 149; MSTP149; MXD 4; MXD4; Mad4 homolog; max dimerizer 4; OTTHUMP00000115253; max-associated protein 4; class C basic helix-loop-helix protein 12; max-interacting transcriptional repressor MAD4;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the MAD gene family. The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.

Pathway

Validated targets of C-MYC transcriptional repression, organism-specific biosystem;