This product (Catalog No. CABT-BL2536) is a rabbit-derived polyclonal antibody raised against human MVD, targeting the amino acid region 1–400 of the protein. This antibody exhibits cross-reactivity with Human MVD from mouse and rat. It has been affinity purified by Protein A. The enzyme mevalonate pyrophosphate decarboxylase(MVD) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate. It is also named as MPD and as a unique enzyme in one of the early steps in cholesterol biosynthesis, MVD may be a useful target for drugs aimed at lowering serum cholesterol levels(PMID:8626466). The intracellular glycosylation does not contribute to the difference between the 45 and 37 kDa species of MVD. The native MVD has a molecular weight of 90 kDa that it consists of two identical subunits of 45 kDa and a 37 kDa protein is also found as a subunit of MVD and this type of MVD may be a 74 kDa.But the 37 kDa enzyme appeared only when the rats are fed the CP diet.(PMID:9348097). CABT-BL2536 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:500), IF/ICC (1:50–1:500) applications. CABT-BL2536 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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