Human MUTYH blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-MUTYH antibody

Target

MUTYH

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function

4 iron, 4 sulfur cluster binding; NOT MutLalpha complex binding; NOT MutLbeta complex binding; MutSalpha complex binding; NOT MutSbeta complex binding; hydrolase activity, acting on glycosyl bonds; metal ion binding; protein binding;

Synonyms

MUTYH; mutY homolog; MYH; CYP2C; A/G-specific adenine DNA glycosylase;