Human MUC4 peptide

Specificity

Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, sq

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Contains 1 AMOP domain.Contains 2 EGF-like domains.Contains 1 NIDO domain.Contains 1 VWFD domain.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]

Function

ErbB-2 class receptor binding; extracellular matrix constituent, lubricant activity;

Synonyms

MUC4; mucin 4, cell surface associated; ASGP; MUC-4; HSA276359; mucin-4; testis mucin; tracheobronchial mucin; ascites sialoglycoprotein; mucin 4, tracheobronchial; pancreatic adenocarcinoma mucin;