Human MSH3 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

Function

ATP binding; DNA-dependent ATPase activity; Y-form DNA binding; centromeric DNA binding; contributes_to dinucleotide insertion or deletion binding; contributes_to dinucleotide repeat insertion binding; double-strand/single-strand DNA junction binding; enz

Synonyms

MSH3; mutS homolog 3; DUP; MRP1; DNA mismatch repair protein Msh3; hMSH3; mismatch repair protein 1; divergent upstream protein;