Human MLH3 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-MLH3 antibody

Target

MLH3

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Function

ATP binding; ATPase activity; centromeric DNA binding; chromatin binding; mismatched DNA binding; mismatched DNA binding; protein binding; satellite DNA binding;

Synonyms

MLH3; mutL homolog 3 (E. coli); mutL (E. coli) homolog 3; DNA mismatch repair protein Mlh3; mutL protein homolog 3; HNPCC7; MGC138372;