Anti-MCM10 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide (Human) - which represented a portion of Minichromosome Maintenance Deficient 10 encoded within exon 14.

Conjugate

Application Notes

IP: 1-4μg/ml
WB: 1:1000-1:5000.

Alternative Names

MCM10; minichromosome maintenance complex component 10; MCM10 minichromosome maintenance deficient 10 (S. cerevisiae); protein MCM10 homolog; CNA43; DNA43; PRO2249; FLJ31133; HsMCM10; mcm10; MCM10 minichromosome maintenance deficient 10; MCM10_HUMAN; Minichromosome maintenance protein 10 isoform 1; PRO2249; Protein MCM10 homolog; hsMCM10; homolog of yeast MCM10; MCM10 minichromosome maintenance deficient 10;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Pathway

Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication, organism-specific biosystem; DNA Replication Pre-Initiation, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G2/M Checkpoints, organism-specific biosyste