Specificity
Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily.Contains 1 kinesin-motor domain.
Alternative Names
The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. [provided by RefSeq, Jul 2008]
Function
ATP binding; centromeric DNA binding; microtubule motor activity; microtubule plus-end binding; protein binding;
Synonyms
KIF2C; kinesin family member 2C; MCAK; CT139; KNSL6; kinesin-like protein KIF2C; kinesin-like 6; kinesin-like protein 6; mitotic centromere-associated kinesin;
Citations
Publication ()
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COA
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