This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Function
peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity;
Synonyms
MAML1; mastermind-like 1 (Drosophila); mastermind (drosophila) like 1; mastermind-like protein 1; KIAA0200; Mam 1; mastermind homolog; Mam1; Mam-1; FLJ53540;
Citations
Publication ()
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