This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Function
DNA binding; protein dimerization activity;
Synonyms
MXD3; MAX dimerization protein 3; MYX; MAD3; BHLHC13; max dimerization protein 3; max dimerizer 3; Max-associated protein 3; class C basic helix-loop-helix protein 13; Max-interacting transcriptional repressor MAD3;
Citations
Publication ()
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