The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Function
DNA binding; cholesterol binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; sterol response element binding; transcription coactivator activity; transcription regulatory region DNA binding; contributes_to transcription regulatory region DNA binding; zinc ion binding
Synonyms
NR1H3; nuclear receptor subfamily 1, group H, member 3; LXRA; LXR-a; RLD-1; oxysterols receptor LXR-alpha; liver X nuclear receptor alpha variant 1
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