Rabbit Anti-Human LRRC25 Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Rat

Immunogen

A synthesized peptide derived from human LRRC25.

Conjugate

Application Notes

WB 1:500-1:2000
IHC 1:50-1:200

General Notes

This product (Catalog No. CABT-BL2209) is a rabbit-derived polyclonal antibody raised against human LRRC25. This antibody exhibits cross-reactivity with LRRC25 from rat. It has been affinity purified by Protein A. Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
CABT-BL2209 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200) applications.
CABT-BL2209 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID