Product Overview
Blocking/Immunizing peptide for anti-LASS1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]
Function
molecular_function; sphingosine N-acyltransferase activity;
Synonyms
CERS1; ceramide synthase 1; LAG1; UOG1; LASS1; protein UOG-1; upstream of GDF1; longevity assurance gene 1 protein homolog 1; longevity assurance (LAG1, S. cerevisiae) homolog 1;
Citations
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Schulz, A; Mousallem, T; et al. The CLN9 protein, a regulator of dihydroceramide synthase. JOURNAL OF BIOLOGICAL CHEMISTRY 281:2784-2794(2006).
Min, JX; Mesika, A; et al. (Dihydro)ceramide synthase 1-regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. MOLECULAR CANCER RESEARCH 5:801-812(2007).