General Notes
This product (Catalog No. CABT-BL2078) is a rabbit-derived polyclonal antibody raised against human KLHL35, targeting the amino acid region 230–363 of the protein. This antibody exhibits cross-reactivity with Human KLHL35 from mouse and rat. It has been affinity purified by Protein A. KLHL35 (Kelch Like Family Member 35) is a member of the Kelch-like protein family characterized by the presence of BTB/POZ and Kelch-repeat domains, which typically mediate protein–protein interactions and substrate recognition in ubiquitin ligase complexes. KLHL35 is thought to function as a substrate adaptor for CUL3-based E3 ubiquitin ligase systems, thereby contributing to the ubiquitination and proteasomal degradation of specific target proteins. Although its precise molecular substrates and cellular pathways remain largely uncharacterized, Kelch family proteins are commonly involved in regulating cytoskeletal organization, cell signaling, and developmental processes. Expression data suggest tissue-specific or developmentally regulated patterns, but detailed functional studies of KLHL35 are still limited. Overall, KLHL35 is considered a putative regulatory protein involved in ubiquitin-mediated proteostasis, awaiting further experimental validation to define its biological roles.
CABT-BL2078 is suitable for use in Western blot (WB) (1:1,000–1:6,000), IHC (1:20–1:200), IF/ICC (1:10–1:100) applications.
CABT-BL2078 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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