The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]
Function
voltage-gated ion channel activity; voltage-gated potassium channel activity;
Synonyms
KCNC3; potassium voltage-gated channel, Shaw-related subfamily, member 3; SCA13, spinocerebellar ataxia 13; potassium voltage-gated channel subfamily C member 3; Kv3.3; voltage-gated potassium channel protein KV3.3; voltage-gated potassium channel subunit Kv3.3; Shaw-related voltage-gated potassium channel protein 3; KV3.3; SCA13; KSHIIID;
Citations
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VEH, RW; LICHTINGHAGEN, R; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF 5 MEMBERS OF THE KV1 CHANNEL SUBUNITS - CONTRASTING SUBCELLULAR LOCATIONS AND NEURON-SPECIFIC CO-LOCALIZATIONS IN RAT-BRAIN. EUROPEAN JOURNAL OF NEUROSCIENCE 7:2189-2205(1995).
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