This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function
RNA binding; histone demethylase activity (H3-R2 specific); histone demethylase activity (H4-R3 specific); identical protein binding; identical protein binding; iron ion binding; peptidyl-lysine 5-dioxygenase activity; protein binding; receptor activity; single-stranded RNA binding
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