Anti-IRF2 monoclonal antibody (DMABT-H14060)

Mouse anti-Human IRF2 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4C6
Species Reactivity
Human
Immunogen
IRF2 (NP_002190, 216 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
IRF2; interferon regulatory factor 2; IRF-2; DKFZp686F0244
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IRF2 (Interferon Regulatory Factor 2) is a Protein Coding gene. Diseases associated with IRF2 include eczema herpeticum and mumps. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is IRF3. IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Antigen Description
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene. IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. The function about IRF2 antigen include DNA binding; protein binding; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity.
Pathway
Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem.

Citations


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References


Grieder, FB; Vogel, SN; et al. Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection. VIROLOGY 257:106-118(1999).
Sharma-Walia, N; Krishnan, HH; et al. ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection. JOURNAL OF VIROLOGY 79:10308-10329(2005).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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