Product Overview
IRAKM peptide ( human )
Tag/Conjugate
Unconjugated
Application Notes
Stable for one year.
Buffer
Preservative: 0.02% Sodium Azide; Constituents: 0.1% BSA, PBS. pH 7.2
Preservative
0.02% Sodium Azide
Antigen Description
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Function
ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity;
Synonyms
IRAK3; interleukin-1 receptor-associated kinase 3; IRAK M; IL-1 receptor-associated kinase M; ASRT5; IRAKM; FLJ13601;
Citations
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Saenger, Y; Magidson, J; et al. Blood mRNA Expression Profiling Predicts Survival in Patients Treated with Tremelimumab. CLINICAL CANCER RESEARCH 20:3310-3318(2014).
Xu, GY; Wen, HP; et al. Involvement of IRAKs and TRAFs in anti-beta(2)GPI/beta(2)GPI-induced tissue factor expression in THP-1 cells. THROMBOSIS AND HAEMOSTASIS 106:1158-1169(2011).