Product Overview
Blocking/Immunizing peptide for anti-IRAK4 (N Terminus) antibody
Target
IRAK4 (N Terminus)
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Function
ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity;
Synonyms
IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64;
Citations
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Kimman, TG; Banus, S; et al. Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination. PLOS ONE 3:-(2008).
Rininsland, F; Stankewicz, C; et al. High-throughput kinase assays with protein substrates using fluorescent polymer superquenching. BMC BIOTECHNOLOGY 5:-(2005).