Rabbit Anti-Human INSL5 (a.a. 49-135) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

Recombinant human INSL5 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 49-135 aa of BC101646

Conjugate

Application Notes

WB: 1:200-1:1000

General Notes

This product (Catalog No. CABT-BL1936) is a rabbit-derived polyclonal antibody raised against human INSL5, targeting the amino acid region 49–135 of the protein. This antibody exhibits cross-reactivity with Human INSL5 from mouse and rat. It has been affinity purified by Protein A. Insulin-like peptide 5 (INSL5), also named as UNQ156/PRO182, is a member of the relaxin/insulin superfamily and presents a tertiary structure similar to that of other insulin family members. It is located outside the cell membranes and highly expressed in rectum with lower levels in uterus and ascending and descending colon (PMID: 10458910). The calculated molecular weight of INSL5 is 15 kDa. A recent report suggested an important role for Isnl5 in the regulation of insulin secretion and b-cell homeostasis. Other reports identified that colonic Isnl5 expression is reduced by the gut microbiota and energy availability. In human diseases, INSL5 has been identified recently in colonic tissue and neuroendocrine tumors, but its specific functions in tumors remain to be elucidated(PMID: 32657028).
CABT-BL1936 is suitable for use in Western blot (WB) (1:200–1:1,000) application.
CABT-BL1936 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

INSL5; insulin like 5; Insulin like peptide 5; Insulin like peptide INSL5; PRO182; UNQ156

Entrez Gene ID

UniProt ID