Anti-ILKAP monoclonal antibody (DMABT-H14047)
Mouse anti-Human ILKAP monoclonal antibody for WB, IHC, sELISA, ELISA
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ILKAP (NP_110395, 293 a.a. ~ 392 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
ILKAP; integrin-linked kinase-associated serine/threonine phosphatase; integrin linked kinase associated serine/threonine phosphatase 2C; integrin-linked kinase-associated serine/threonine phosphatase 2C; DKFZP434J2031; FLJ10181
ILKAP (ILK Associated Serine/Threonine Phosphatase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E. The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene. 0The function about ILKAP antigen include hydrolase activity; metal ion binding; protein binding; protein serine/threonine phosphatase activity.
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Schorradt, C; Eke, I; et al. Protein phosphatase ILKAP regulates the cellular Radiosensitivity of human Glioblastoma cells. STRAHLENTHERAPIE UND ONKOLOGIE 188:117-117(2012).
Hojlys-Larsen, KB; Sorensen, KK; et al. Probing protein phosphatase substrate binding: affinity pull-down of ILKAP phosphatase 2C with phosphopeptides. MOLECULAR BIOSYSTEMS 8:1452-1460(2012).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.