Anti-ILKAP monoclonal antibody (DMABT-H14047)

Mouse anti-Human ILKAP monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
4C6
Species Reactivity
Human
Immunogen
ILKAP (NP_110395, 293 a.a. ~ 392 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
ILKAP; integrin-linked kinase-associated serine/threonine phosphatase; integrin linked kinase associated serine/threonine phosphatase 2C; integrin-linked kinase-associated serine/threonine phosphatase 2C; DKFZP434J2031; FLJ10181
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ILKAP (ILK Associated Serine/Threonine Phosphatase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1E. The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
Antigen Description
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene. 0The function about ILKAP antigen include hydrolase activity; metal ion binding; protein binding; protein serine/threonine phosphatase activity.

Citations


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References


Cengiz, B; Gunduz, E; et al. Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma. INTERNATIONAL JOURNAL OF CANCER 127:2088-2094(2010).
Baciu, C; Thompson, KJ; et al. The LO-BaFL method and ALS microarray expression analysis. BMC BIOINFORMATICS 13:-(2012).

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