Rabbit Anti-Human IL28RA (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human IL28RA, corresponding to a region within the internal amino acids.

Conjugate

Application Notes

IHC 1:50-1:200
WB 1:1000-3000

General Notes

This product (Catalog No. CABT-BL1925) is a rabbit-derived polyclonal antibody raised against human IL28RA. It has been affinity purified by Protein A. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
CABT-BL1925 is suitable for use in IHC 1 (50-1:200), WB 1 (1000-3000) applications.
CABT-BL1925 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID