Human IL17F peptide

Name: Human IL17F peptide
SKU: DAG-P0614
Rating: 5 (1 reviews)

Synthetic Human IL17F peptide

COA

SDS

Datasheet

Summary

Specificity

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the IL-17 family.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

112744

Antigen Description

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Function

cytokine activity; cytokine binding; cytokine receptor binding; protein homodimerization activity;

Synonyms

IL17F; interleukin 17F; ML1; ML-1; CANDF6; IL-17F; interleukin-17F; cytokine ML-1;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

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References

Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects

HUMAN IMMUNOLOGY

Authors: Wang, Min; Zhang, Yuan; Han, Demin; Zhang, Luo

Abstract

Background: Th17 cell lineage, a distinct pro-inflammatory lineage characterized by preferential synthesis of cytokines IL-17A and IL-17F, is thought to play an important role in the pathogenesis of allergic rhinitis (AR). Objectives: Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma. Methods: A case-control comparison was performed in a cohort of 279 AR patients, 197 allergic rhinitis with asthma (AR-A) patients and 281 control Chinese subjects, to investigate associations between 19 tagging single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F gene regions and manifestation of AR or AR-A. Genotyping was performed using the Sequenom MassARRAY platform. Results: SNP rs3819024 in IL-17A gene, intergenic SNPs rs1892280 and rs10807439 were specifically associated with AR protective or risk effects, while rs3819024 in IL-17A gene, intergenic SNP rs13192563 in 1L-17F gene were associated with AR-A protective or risk effects. Haplotype analysis showed significant AR risk in haplotype AA (rs1892280G-rs13192563A) and AR protective effect in haplotype GT (rs7758579A-rs119667601); the haplotype AT(rs7758579-rs11966760) were considered AR-A risk. Conclusions: Our findings preliminarily indicate IL17A and IL17F SNPs, and some intergenic variants have the potential association with AR and comorbid asthma in Chinese population. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

The IL17F and IL17RA Genetic Variants Increase Risk of Cerebral Malaria in Two African Populations

INFECTION AND IMMUNITY

Authors: Marquet, Sandrine; Conte, Ianina; Poudiougou, Belco; Argiro, Laurent; Cabantous, Sandrine; Dessein, Helia; Burte, Florence; Oumar, Aboubacar A.; Brown, Biobele J.; Traore, Abdoualye; Afolabi, Nathaniel K.; Barry, Abdoulaye; Omokhodion, Samuel; Ndoumbe, Ursule Ewanda; Shokunbi, Wuraola A.; Sodeinde, Olugbemiro; Doumbo, Ogobara; Fernandez-Reyes, Delmiro; Dessein, Alain J.

Abstract

Cerebral malaria (CM) is a neurological complication of infection with Plasmodium falciparum that is partly caused by cytokine-mediated inflammation. It is not known whether interleukin-17 (IL-17) cytokines, which regulate inflammation, control the development of CM. To evaluate the involvement of IL-17 cytokines in CM, we analyzed 46 common polymorphisms in IL17A, IL17F, and IL17RA (which encodes the common receptor chain of the members of the IL-17 family) in two independent African populations. A case-control study involving 115 Nigerian children with CM and 160 controls from the community (CC) showed that IL17F reference single nucleotide polymorphism (SNP) 6913472 (rs6913472) (P = 0.004; odds ratio [OR] = 3.12), IL17F rs4715291 (P = 0.004; OR = 2.82), IL17RA rs12159217 (P = 0.01; OR = 2.27), and IL17RA rs41396547 (P = 0.026; OR = 3.15) were independently associated with CM. A replication study was performed in 240 nuclear Malian family trios (two parents with one CM child). We replicated the association for 3 SNPs, IL17F rs6913472 (P = 0.03; OR = 1.39), IL17RA rs12159217 (P = 0.01; OR = 1.52), and IL17RA rs41396547 (P = 0.04; OR = 3.50). We also found that one additional SNP, IL17RA rs41433045, in linkage disequilibrium (LD) with rs41396547, was associated with CM in both Nigeria and Mali (P = 0.002; OR = 4.12 in the combined sample). We excluded the possibility that SNPs outside IL17F and IL17RA, in strong LD with the associated SNPs, could account for the observed associations. Furthermore, the results of a functional study indicated that the aggravating GA genotype of IL17F rs6913472 was associated with lower IL-17F concentrations. Our findings show for the first time that IL17F and IL17RA polymorphisms modulate susceptibility to CM and provide evidence that IL-17F protects against CM.