Rabbit Anti-Human IL12RB2 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human interleukin 12 receptor, beta 2

Conjugate

Application Notes

IHC: 1:50-1:200

General Notes

This product (Catalog No. CABT-BL4917) is a rabbit-derived IgG polyclonal antibody raised against human IL12RB2. It has been affinity purified by protein A. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
CABT-BL4917 is suitable for use in IHC (1:50–1:200) application.
CABT-BL4917 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

RP11-102M16.1

Entrez Gene ID

UniProt ID