Synthetic Human IKZF1 blocking peptide for Apuri, BL, ELISA
Blocking/Immunizing peptide for anti-IKAROS/IKZF1 antibody
Human, Cow, Dog
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Shipped at ambient temperature, store at -20°C.
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
DNA binding; metal ion binding; nucleic acid binding; protein heterodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;
IKZF1; IKAROS family zinc finger 1 (Ikaros); zinc finger protein, subfamily 1A, 1 (Ikaros) , ZNFN1A1; DNA-binding protein Ikaros; hIk 1; Hs.54452; IKAROS; LyF 1; CLL-associated antigen KW-6; Ikaros (zinc finger protein); ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein, subfamily 1A, 1 (Ikaros); IK1; LYF1; hIk-1; PRO0758; ZNFN1A1;