Human IGSF8 peptide

Specificity

Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Alternative Names

The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Function

protein binding;

Synonyms

IGSF8; immunoglobulin superfamily, member 8; EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1; immunoglobulin superfamily member 8; CD81 partner 3; prostaglandin regulatory-like protein; glu-Trp-Ile EWI motif-containing protein 2; keratinocytes-associated transmembrane protein 4;