Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Function
interferon-gamma receptor activity;
Synonyms
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1); AF-1; IFGR2; IFNGT1; interferon gamma receptor 2; IFN-gamma-R2; IFN-gamma receptor 2; interferon gamma transducer 1; interferon gamma receptor beta chain; interferon gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1;
Citations
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Ivanidze, J; Hoffmann, R; et al. Inclusion Body Myositis Laser Microdissection Reveals Differential Up-Regulation of IFN-gamma Signaling Cascade in Attacked versus Nonattacked Myofibers. AMERICAN JOURNAL OF PATHOLOGY 179:1347-1359(2011).
Pant, SD; Verschoor, CP; et al. Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. MAMMALIAN GENOME 22:583-588(2011).