General Notes
This product (Catalog No. CABT-BL1890) is a rabbit-derived polyclonal antibody raised against human IFITM5. It has been affinity purified by Protein A. Interferon-induced transmembrane protein 5 (IFITM5) is a membrane protein encoded by the IFITM5 gene in humans, primarily expressed in bone tissue where it plays a key role in osteoblast function and bone matrix mineralization. The gene is located on the short arm of chromosome 11 at position 11p15.5 and consists of two exons, producing a small transmembrane protein with a conserved CD225 domain characteristic of the interferon-induced transmembrane (IFITM) family, though IFITM5 itself is not inducible by interferons. Despite its name suggesting involvement in immune responses, IFITM5 is bone-restricted and essential for proper bone formation, with disruptions leading to skeletal disorders.
CABT-BL1890 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
CABT-BL1890 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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