Synthetic peptide within Mouse ICOS Ligand aa 300 to the C-terminus conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9JHJ8
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
Pathway
Adaptive Immune System; Cell adhesion molecules (CAMs); Immune System; Intestinal immune network for IgA production
Citations
Publication ()
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