Product Overview
Recombinant Full-Length H3N2 A/Wisconsin/67/05 is glycosylated with N-linked sugars, produced using baculovirus vectors in insect cells and its Mw is 70, 000 dalton.
Alternative Names
Influenzavirus A; Influenza A virus; Influenza A virus H3N2; H3N2; IAV H3N2; IAV H3N2 Hemagglutinin; IAV H3N2 HA; H3N2 HA
Purity
Greater than 90.0% as determined by SDS-PAGE.
Buffer
10mM Sodium phosphate, pH 7.4, 150mM NaCl and 0.005% Tween-20.
Introduction
Hemagglutinin (HA) or Haemagglutinin (BE) is an antigenic glycoprotein found on the surface of the influenza viruses. It is responsible for binding the virus to the cell that is being infected. The name "Hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together ("agglutinate") in vitro. The process is like this: Hemagglutinin (HA) binds to the monosaccharide sialic acid which is present on the surface of its target host cells. The cell membrane then engulfs the virus through endocytosis and forms endosome. The cell then attempts to begin digesting the contents of the endosome by acidifying its interior and transforming it into a lysosome. When the pH within the endosome drops to 6.0, the HA molecule becomes partially unfold, and releasing a very hydrophobic portion of its peptide chain that was previously hidden within the protein. This so-called "fusion peptide" acts like a molecular grappling hook by inserting itself into the endosomal membrane and locking on. Then, when the rest of the HA molecule refolds into a new structure and pulls the endosomal membrane right up next to the virus particle's own membrane, causing the two to fuse together. Once this has happened, the viral RNA genome enters into the cell's cytoplasm.
Keywords
Influenzavirus A; Influenza A virus; Influenza A virus H3N2; H3N2; IAV H3N2; IAV H3N2 Hemagglutinin; IAV H3N2 HA; H3N2 HA
Citations
Publication ()
Have you cited DAG1612 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
