Product Overview
Recombinant Full-Length H1N1 A/Solomon Islands/03/2006 is glycosylated with N-linked sugars, produced using baculovirus vectors in insect cells.
Alternative Names
Influenzavirus A; Influenza A virus; Influenza A virus H1N1; H1N1; IAV H1N1; IAV H1N1 Hemagglutinin; IAV H1N1 HA; H1N1 HA
Purity
Greater than 90.0% as determined by SDS-PAGE.
Buffer
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol.
Storage
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Introduction
Hemagglutinin (HA) or Haemagglutinin (BE) is an antigenic glycoprotein found on the surface of the influenza viruses. It is responsible for binding the virus to the cell that is being infected. The name "Hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together ("agglutinate") in vitro. The process is like this: Hemagglutinin (HA) binds to the monosaccharide sialic acid which is present on the surface of its target host cells. The cell membrane then engulfs the virus through endocytosis and forms endosome. The cell then attempts to begin digesting the contents of the endosome by acidifying its interior and transforming it into a lysosome. When the pH within the endosome drops to 6.0, the HA molecule becomes partially unfold, and releasing a very hydrophobic portion of its peptide chain that was previously hidden within the protein. This so-called "fusion peptide" acts like a molecular grappling hook by inserting itself into the endosomal membrane and locking on. Then, when the rest of the HA molecule refolds into a new structure and pulls the endosomal membrane right up next to the virus particle's own membrane, causing the two to fuse together. Once this has happened, the viral RNA genome enters into the cell's cytoplasm.
Keywords
Influenzavirus A; Influenza A virus; Influenza A virus H1N1; H1N1; IAV H1N1; IAV H1N1 Hemagglutinin; IAV H1N1 HA; H1N1 HA
Citations
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