Human TL-1A ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant TL-1A in a sandwich ELISA format. Using the ELISA protocol described below, this kit provides sufficient reagents to assay TL-1A in approximately 1500 ELISA plate wells.
Contents of Kit
1. Capture Antibody 2. Detection Antibody 3. Standard 4. StreptAvidin-HRP 5. TMB Liquid Substrate "Ready to Use"
Storage
See "Reagent Preparation"
General Description
TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.1 TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.2
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