Disruption of the estradiol-regulated NTN1-UNC5A dependence receptor signaling axis causes a hybrid basal/ luminal molecular phenotype in estrogen receptor-positive breast cancer cells
CANCER RESEARCH
Authors: Padua, M. B.; Bhat-Nakshatri, P.; Anjanappa, M.; Hao, Y.; Liu, Y.; McElyea, K.; Sandusky, G.; Althouse, S.; Perkins, S.; Nakshatri, H.
Abstract
NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population
ORAL DISEASES
Authors: Jiang, ShuYuan; Shi, Jia-Yu; Lin, Yan-Song; Duan, Shi-Jun; Chen, Xieli; Jiao, Jian-Jun; Shen, Wei; Jin, Xiaoju; You, Miao; Wang, Moyao; Shi, Bing; Jia, Zhong-Lin
Abstract
Objective Genome-wide association studies (GWAS) found NTN1, NOG and the region between CREBBP and ADCY9 were risks to non-syndromic cleft lip with or without cleft palate (NSCL/P). However, the association of single nucleotide polymorphisms (SNPs) in these genes with NSCL/P in Western China is unknown. Subjects and Methods We selected seven SNPs in NTN1, NOG and between CREBBP and ADCY9, and then performed transmission disequilibrium test (TDT), parent-of-origin effect and sliding window haplotype analysis to test the associations among 302 NSCL/P case-parent trios from Western Han Chinese. Results We found allele G at rs4791774 in NTN1 was significantly overtransmitted among non-syndromic cleft lip only (NSCLO) (p = 0.0067, OR = 1.79, 95% CI: 1.17-2.74); rs4791774 and rs9915089 tightly linked with each other among NSCL/P (D ' = 0.87, r(2) = 0.67) and haplotypes carrying the risk allele G at rs4791774 were always found to be overtransmitted from parents to cases. Motif analysis indicated that allele G at rs4791774 could greatly alter the affinity of Myc_disc7, so allele G at rs4791774 in NTN1 might modulate C-MYC transcription to participate in the aetiology of NSCLO. Conclusions Our study suggested allele G at rs4791774 in NTN1 gene is risk of NSCLO, which could greatly increase the risk to have a baby with cleft.
COA
Publication 
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